Ketoconazole is a broad-spectrum imidazole antifungal that inhibits ergosterol synthesis, disrupting fungal cell membrane integrity. It is effective against dermatophytes (Trichophyton, Microsporum, Epidermophyton), yeasts (Candida, Malassezia), and other fungi. This medicated soap is indicated for tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot), tinea versicolor (pityriasis versicolor), and seborrheic dermatitis (dandruff). It relieves itching, scaling, and irritation while preventing recurrence.
Ketoconazole belongs to the imidazole class of antifungals. It inhibits the fungal enzyme
lanosterol 14α-demethylase (cytochrome P450 14DM), blocking the conversion of lanosterol to ergosterol,
an essential component of the fungal cell membrane. This leads to increased membrane permeability,
leakage of cellular contents, and ultimately fungal cell death.
The 2% w/w concentration is optimal for treating superficial fungal infections. The soap formulation
allows for easy application over large body areas and is particularly effective for seborrheic dermatitis
(dandruff) when used on the scalp and face (avoiding eyes). Clinical improvement is usually seen within
1–2 weeks, with complete resolution in 4–6 weeks for tinea infections.
Spectrum of activity: Dermatophytes (Trichophyton rubrum, T. mentagrophytes,
Microsporum canis, Epidermophyton floccosum), Yeasts (Candida albicans, Malassezia furfur),
and other fungi.
| Active Ingredient (per 100g) | Ketoconazole IP 2g (2% w/w) |
|---|---|
| Other Ingredients | Soap base (sodium palmate, sodium cocoate), glycerin, purified water, fragrance (mild), permitted color. |
| Allergen Information | Free from parabens, SLS, and artificial dyes. Suitable for sensitive skin (fragrance-free option available). |
Wet the affected area with water. Lather the soap and apply to the infected skin, leaving the lather on for 3–5 minutes before rinsing thoroughly. For tinea infections, use twice daily for 2–4 weeks. For seborrheic dermatitis/dandruff, use on the scalp and face (avoid eyes) 2–3 times weekly for 2–4 weeks, then once weekly for maintenance. For athlete's foot, apply between toes and leave for 5 minutes before rinsing. Continue using for at least 1 week after symptoms clear to prevent recurrence.
| Dosage Form | Solid medicated soap bar |
|---|---|
| Net Weight | 75g ± 5% |
| Packaging | Single bar in sealed poly wrapper, 100 bars per carton |
| Manufacturing Standard | WHO-GMP, ISO 22716 (Cosmetics GMP) |
| Shelf Life | 24 months from date of manufacture |
| Country of Origin | India |
| Minimum Order Qty | 1000 bars (10 cartons of 100 bars) |
Ketoconazole soap is generally well tolerated. Rare side effects may include:
Store below 30°C (86°F) in a cool, dry place. Avoid direct sunlight and heat.
Keep soap in a dry, draining soap dish. Do not immerse in water for long periods.
Full export docs: COA, Stability data, GMP certificate, FSC, MSDS, commercial invoice. Ambient shipping.
