Methylcobalamin is the active coenzyme form of vitamin B12, directly utilized by the nervous system without needing hepatic conversion. It promotes myelin synthesis, enhances nerve conduction velocity, and facilitates axonal regeneration. Intramuscular or intravenous administration achieves rapid, high bioavailability – ideal for diabetic neuropathy, alcoholic neuropathy, herniated disc radiculopathy, and vitamin B12 deficiency (pernicious anemia, malabsorption). It also reduces homocysteine levels, protecting against vascular and neurodegenerative diseases.
Methylcobalamin (MeCbl) is one of two active coenzyme forms of vitamin B12 (the other being adenosylcobalamin).
It acts as a cofactor for methionine synthase, which converts homocysteine to methionine, essential for myelin synthesis.
It also plays a role in DNA synthesis, fatty acid metabolism, and energy production.
Neuroprotective effects: Promotes axonal regeneration, enhances Schwann cell proliferation, and improves nerve conduction velocity.
Clinical studies show significant improvement in neuropathic symptoms (numbness, tingling, burning) after 4–8 weeks of treatment.
Homocysteine reduction: Elevated homocysteine is a risk factor for stroke, dementia, and neuropathy. Methylcobalamin lowers homocysteine levels, providing vascular protection.
Intramuscular injection bypasses gastrointestinal absorption issues (common in elderly, atrophic gastritis, Crohn's disease, post-gastric surgery), achieving 100% bioavailability.
| Active Ingredient | Methylcobalamin IP – 1500 mcg (1.5 mg) per 1 ml |
|---|---|
| Excipients | Sodium chloride (tonicity adjuster), benzyl alcohol (preservative), water for injection, sodium hydroxide/hydrochloric acid (pH adjuster). |
| pH Range | 5.0 – 7.0 |
| Osmolality | Approximately 300 mOsm/kg |
Diabetic neuropathy / peripheral neuropathy: 1500 mcg intramuscularly three times per week for 4 weeks, then 1500 mcg once weekly for maintenance.
Vitamin B12 deficiency (megaloblastic anemia): 1500 mcg intramuscularly once daily for 1 week, then 1500 mcg once weekly for 4 weeks, then 1500 mcg monthly.
Herniated disc / radiculopathy: 1500 mcg intramuscularly daily for 10 days, then alternate days for 2 weeks.
Trigeminal neuralgia: 1500 mcg intramuscularly three times weekly for 8 weeks.
For IM injection: Inject deeply into the gluteal or deltoid muscle. Aspirate to avoid intravascular injection. For IV injection: May be given slowly (over 2-3 minutes) or added to IV infusion fluids. Protect the solution from light during infusion. Use immediately after opening; discard any unused portion.
| Dosage Form | Sterile, clear red solution in glass ampoule (light-sensitive) |
|---|---|
| Strength | 1500 mcg per 1 ml ampoule |
| Packaging | 5 ampoules per blister pack, 20 blisters per carton (100 ampoules/carton) |
| Manufacturing Standard | WHO-GMP, ISO 13485 (sterile injectables) | Shelf Life | 24 months from date of manufacture |
| Country of Origin | India |
| Minimum Order Qty | 1000 ampoules (10 cartons) |
Methylcobalamin is extremely safe, even at high doses. Rare side effects may include:
Hypokalemia: When treating severe megaloblastic anemia, vitamin B12 can cause rapid erythropoiesis, leading to hypokalemia.
Monitor serum potassium levels during initial therapy.
Leber's optic atrophy: Methylcobalamin is generally contraindicated in patients with Leber's disease (hereditary optic nerve atrophy) as it may worsen symptoms.
Pregnancy & lactation: Safe in recommended doses (FDA Category C – no risk in humans). Consult physician.
Store below 25°C (77°F), protected from light. Light-sensitive – keep ampoules in original carton until use.
Do not freeze. If precipitate forms, discard. Once opened, use immediately.
Full export docs: COA, Stability data, GMP certificate, FSC, MSDS, commercial invoice. Ambient shipping, protect from light.
