Pregabalin reduces neuropathic pain by binding to calcium channels and decreasing neurotransmitter release. Methylcobalamin (active B12) promotes myelin synthesis, repairs damaged nerves, and improves nerve conduction velocity. Together, they address both symptomatic pain and underlying nerve damage — ideal for diabetic neuropathy, post-herpetic neuralgia, and peripheral neuropathies.
Pregabalin is a gabapentinoid that binds to the α2-δ subunit of voltage-gated calcium channels, reducing
calcium influx and decreasing the release of excitatory neurotransmitters (glutamate, norepinephrine, substance P).
This provides rapid symptomatic relief from neuropathic pain, often within 1–2 weeks.
Methylcobalamin is the active coenzyme form of vitamin B12. It acts as a cofactor for methionine synthase,
crucial for myelin synthesis and nerve repair. It also reduces homocysteine levels (a neurotoxic metabolite)
and promotes axonal regeneration. Clinical studies show that adding Methylcobalamin to Pregabalin improves
pain scores, nerve conduction velocities, and quality of life compared to Pregabalin alone.
| Parameter | Pregabalin alone | Pregabalin + Methylcobalamin |
|---|---|---|
| Pain reduction (VAS 0-10) | 2.9 points | 4.1 points |
| Nerve conduction velocity improvement | Minimal | Significant (+15-20%) |
| Myelin repair (MRI markers) | None | Positive |
| Quality of life (SF-36 score) | Moderate improvement | Substantial improvement |
| Time to meaningful relief | 2–3 weeks | 1–2 weeks |
This combination is particularly beneficial for diabetic neuropathy where both pain and nerve degeneration coexist.
Initial dose: One capsule (Pregabalin 75 mg + Methylcobalamin 1500 mcg) once daily at bedtime.
Titration: After 1 week, may increase to one capsule twice daily (morning and evening) if needed.
Maintenance: 75–150 mg Pregabalin per day. Maximum 300 mg Pregabalin per day.
Duration: Minimum 3 months for nerve regeneration benefits.
Creatinine clearance (CrCl) 30–60 mL/min: start with 75 mg once daily. CrCl <30 mL/min: 75 mg every other day. Not recommended for CrCl <15 mL/min.
Swallow capsules whole with water. Take with food to reduce dizziness. Do not crush or chew. Abrupt discontinuation may cause withdrawal symptoms (insomnia, nausea, headache) – taper over at least 1 week.
| Composition | Pregabalin IP 75 mg + Methylcobalamin IP 1500 mcg |
|---|---|
| Dosage Form | Hard gelatin capsules |
| Packaging | 10×10 Alu-Alu blister (100 capsules per carton) | Therapeutic Class | Gabapentinoid + Vitamin B12 analogue |
| Drug Schedule | Schedule H (Prescription only) |
| Manufacturing Standard | WHO-GMP, ISO 9001:2015 |
| Dissolution specification | Pregabalin: >80% in 45 min; Methylcobalamin: >75% in 60 min |
| Storage | Below 30°C, protect from moisture |
| MOQ | 500 units (5 cartons) |
Generally well-tolerated. Most common adverse effects (usually mild and transient):
Store below 30°C (86°F) in a cool, dry place. Protect from direct sunlight.
Keep in original Alu-Alu blister pack until use. Do not transfer to pill boxes.
Full export docs: COA, Stability data, GMP certificate, FSC, MSDS, commercial invoice. Ambient shipping, no cold chain required.
